User friendly, costs By che fai
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Adaware
AVG antivirus
Both free and great.
Lavasoft's ad-aware is the best Anti Spyware and its free. you can download a personal edition from www.lavasoft.com or download.com
Avast and lavasoft. You can use both of them simutaneously. They're great!
Spybot: search and destroy
go to www.downloads.com to get it, it is free. plus you can get AVG antivirus there too (free also)
I use Norton System Works, it gives you a wide range of diagnostics and protection including virus protection. Googe it to find out more, local stores have it it on sale for $0 after rebates.
Since you asked for the best, here it is:
Norton Antivirus
Security purposes:
Symantec.